I would hate to try to write a macro for "sweet expressions". The parens show the structure, and the whole point of representing programs as their own literal structure is that it's easy to manipulate.
Without that, why am I using Lisp? If I just want a reasonably high-level language but don't care about macros (or other features that rely on seeing the actual structure clearly), why wouldn't I just use Ruby/Python/Smalltalk? They're pretty good, too.
I can almost guarantee it's going to be more pleasant, down the road, using one of those languages as it's intended to be used, rather than trying to contort Lisp this way. Getting an answer to a Lisp question on StackOverflow is hard enough with standard syntax. No Lisp programmer is going to want to help with a program written like this.