It's a very cool and impressive project, but I wouldn't use it to write an application. Besides cost, the biggest reasons to use these instead of Cortex-A chips are power efficiency and simplicity, and implementing things like process isolation in software seems like throwing all that out the window.
But on the other hand, if your device will be plugged in and power consumption isn't a huge concern, I could definitely see the appeal to having things like a Ruby interpreter or an X server running on your MCU. You could compile and deploy existing code, ideally. But I bet it would take more time to get all of that working well than it would to just write your application with an SDK and an RTOS.
Also, I'm guessing this project predates the STM32MP1: https://www.st.com/en/microcontrollers-microprocessors/stm32...