However, choose your persistence carefully. The open-source Smalltalk landscape is littered with abandon-ware databases.
If you want an OODB, you can just save the image itself, use Magma (an open-source OODB, but its not very wel documented) or use Gemstone (through GLASS), which is commercial but well documented.
SQL support is weak if you want a nice ORM (like Rails' Active Record), and I've had success using CouchDB (a JSON document pretty much just maps straight to an object: keys -> values = instVars -> values).