Syntax is a secondary concern for all but short-term, small-scale programming.
When it comes to making scalable software systems (scalable in every sense of the term, not just performance but also feature growth etc.), syntax is really not the biggest concern; as such, optimizing for syntax can be detrimental to other more important aspects (e.g composability, reusability, programmability), and focusing on syntax means you're not paying attention to the really critical stuff.
I mostly work in Clojure where _all_ operations use prefix syntax (e.g you write (+ A B C) instead of (A + B + C) for addition, and + is just a function). Trust me, it's unfamiliar at first, but it makes reasoning about the program MUCH saner than all the special cases and irregularities that language designer bake into the language just to make some operations infix.