It doesn’t have to be 50000 years. For example: I trust that drinking cow milk won’t kill me even though it hasn’t been common for long. Can’t say the same for GM food.
Yes, but if you zoom out to categories that broad, GM food still fits within them. GM foods are not any less like foods eaten tens or hundreds of thousands of years ago than anything else we eat.
Meat fed cows and trans fats were products of the same relatively (compared to both the inherent nature and existing regulatory framework requiring proof of safety of novel food element of and faced by GMOs on the former case, and the latter of those in the latter case) uncontrolled evolution of food supply that characterizes the long history of “safe” food against which GMOs are contrasted.