Think of a fun idea, doesn't have to be academically innovative, just something useful to people and start cranking on it. I did that. I have a full time job from it now and holy shit do I love it. There are days I work 12 hours, but you know what? I feel awesome afterwards. After a 12 hour day in the office of company x I always needed a beer and bitched about shit for half a day.
Sorry for all the french. I just can't stress these points enough - same points Smith is making, really. I don't even make "a lot" of money, just enough to be upper middle class. I love my work, my life feels fulfilling, and I have money to do what I want with it.
If you don't have kids, I recommend waiting on that ride - it's tough enough that you have a wife. Hopefully she's a cool chick and will support/help you during transition and well into the wild journey of working for yourself.
[EDIT] To clarify the final paragraph: I don't mean to rag on wives/girlfriends (I have a girlfriend), it's just that, if she isn't a cool person and you are emotionally dependent then you lose a certain amount of autonomy and freedom to move around and do things (like leave your job and move into a two bedroom apartment). My girl happily downsized from a house to a two bedroom apartment when we moved to San Diego. It took her a year, but she sold the majority of her junk and we are now much happier (TBH). We also don't share finances (I have a thing against that) so it helped her save some money for other things/experiences as well.