Sure, it will create some issues during the first stages of this migration, but, more than once, I botched my system in the past with the needed i386 libraries (it didn't happen lately, can't tell if because I finally got my head around it of because they improved the tooling).
Still, in the end, we will all have a "cleaner" system. Either because they migrate parts of the Windows calling to 64bit or because they will keep everything neatly in containers, or, probably, due to a mix of both. But it's high time we improve the current state of these tools.
P.S.: Still trying to get WINASIO to work properly with Wine using one of the latest versions (I am trying to run Ableton in Wine, but the latency is just too high). If anyone has experience doing this, any tips would be apreciated.