I totally get this. I started a Makerspace, and was enchanted by the possibilities present in the dense technology I had gathered.
Many of the projects I had always wanted to do were suddenly within reach, and I learned a lot, and made lots of cool things.
Now though, when I talk to people there, and they ask me what I'm working on, I have no good answer. All the low hanging fruit that I had been reaching for has already been picked. The interesting problems to me are still out of reach, and now require even more specialized equipment or technology.
If anyone has a spare MRI machine or electron microscope they want to get rid of, I'll take it!