That is still beyond humans with present day life spans, but extend life span to ~1000 years or go full AI and you can totally ride the "devil's pogo stick" to stars <=20ly or so awat.
Fusion rockets would probably be better. I mention Orion because we sort of know how to build it today... at ludicrous cost. No new physics and not that much fundamentally new engineering is needed. Orion is a fabulous and quite valid counter to the folks that seem to like to repeat the canard that interstellar flight is impossible. Hard as hell, sure, but not impossible by any means.
To a fully Kardashev type I civilization it might be around Apollo moon shot difficulty.