Nature is a high impact factor, prestigious journal. It’s million sub-journals, like Nature Metabolism ... well, vary. A lot. They mostly coast on papa’s brand recognition.

Nature Endocrinology Reviews is a relatively ranking journal in endocrinology - roughly second place, by impact factor. This didn’t get published there.

Nature Metabolism was only opened in 2017, as an online-only journal. It doesn’t even rank in the top 50 for endocrine and metabolism journals - granted, that may be in part because it doesn’t even have an impact factor yet (calculating impact factor requires two years of publication history preceding the year being calculated for. In 2020, we should see a 2019 IF.)

So, one can say they might be enormously prestigious, and we just won’t see until 2020. It’s more likely that people aren’t bothering publishing their best articles in a 0 IF journal, because in academic circles the Nature Subbrand is recognized as not inherently meaningful, so the 0 IF pub just hurts (unless you think your pub would otherwise end up in an unimpressive journal, and you want to gamble that the future IF will be higher and pay off.)

Only if the right people were involved in the study.