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After turning Grayscale on, it took me 2x the time to go back and disable it, because i was looking for the "blue" icon and had a hard time distinguishing between all the icons.

Color helps in _saving_ me time as well -- so let's not forget that :)

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You bring up an interesting point. Having controls that stand out and grab attention is good when you don't regularly use them. But while working, in most cases you'll already know the interface well, and don't need it to stick out in order to use it efficiently.

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