tl;dl around 20:45: They're comparing javascript and the tools you use for it to transportation modes. Saying things like Angular was the H2, React is the H3, vanilla javascript is riding a bike. They really are just saying don't over engineer things and use the right tools for the job.
Douglas Crockford's Javascript the Good Parts, is imo the best when it comes to getting a feel for what the right/wrong tools are. That book was a perspective changer for me. People like to get very passionate about frameworks and how Javascript should be done. JS The Good Parts made me realize it's better to play the strengths of what's available to you here and now. To accept the tooling as it is with its pros and cons - exploit the strengths and minimize the impact of the cons.