LaTeX or TeX is a good way, especially if you're sending select people the PDFs directly, not putting it into some awful resume farm that tries to process it into some other form (and then someone possibly uses the badly-processed resumes as an excuse to cull, or resumes simply never show up in searches, or processed resumes look bad when someone sees it).
My current one, which I'm determined to keep to one page, starts like the below, in which I often have to tweak things like page margins and vertical gaps (until recently, it was 11pt, and I'd prefer 12pt). I also recently experimented with putting everything in a single chronology, including degrees, and dropping headings, with no separate skills section. I have no idea what's better, so I'm just reconciling the resume with personal style, which says one page, schools are a privilege rather than a bragging point, experience is more important than keyword spamming, and I don't want a keyword-searched job anyway.
\documentclass[10pt,letterpaper]{article}
\usepackage[letterpaper,margin=1in,top=0.5in,bottom=0.3in]{geometry}
\usepackage[scaled]{helvet}
\usepackage[T1]{fontenc}
% \usepackage[none]{hyphenat}
\pagestyle{empty}
\setlength{\tabcolsep}{0em}
\newcommand{\Section}[1]{%
\vspace{12pt}
\noindent{\large\textbf{\textsf{#1}}}}
\newenvironment{HeaderDateDesc}[2]{%
\vspace{6pt}
\noindent\begin{tabular*}{\linewidth}{l@{\extracolsep{\fill}}r}
\textbf{\textsf{#1}} & \textsf{#2} \\
\end{tabular*}
{}}
\newcommand{\DescBreak}[0]{%
\vspace{4pt}\noindent}
\newcommand{\Caps}[1]{%
{\small #1}}
% http://tex.stackexchange.com/questions/4302/prettiest-way-to-typeset-c-cplusplus
\newcommand{\Cplusplus}{%
C\nolinebreak\hspace{-.05em}\raisebox{.4ex}{\tiny\bf +}\nolinebreak\hspace{-.10em}\raisebox{.4ex}{\tiny\bf +}}
\newcommand{\CandCplusplus}{C/\Cplusplus{}}
\begin{document}
\begin{center}
{\textbf{\textsf{Jane Smith}}}\\
{\small \textsf{Cambridge, Mass., \Caps{USA}}}\\
\texttt{jsmith@example.com}
\end{center}
%\vspace{-16pt}
%\Section{EXPERIENCE}
\begin{HeaderDateDesc}{Principal Engineer, Example LLC}{2012--Present}
...