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JungleDisk might do what you are looking for (not that I know what it is that you are looking for!)

http://www.jungledisk.com/

There is a lot of upcoming work on pricing and plans.

You can think of 250GB to store in a Dropbox? If its backups, surely S3 etc would be better suited?

Not that I object to them providing bigger - I certain see no harm for them to do so.

"64KB ought to be enough for everyone"

The actual number for that quote is 640KB, not 64KB—but I get what you were trying to say.

There is no quote, its a rumor - according to Gates anyhow. He claims he never said that.

Photos, Music, Video. It all adds up.

Oh and my .vimrc is about 3gb now too.

Excuse my ignorance, but what's in in a .vimrc that will make it that large?

emacs

I sync everything in my system with Dropbox using symlinks. It is really easy to get into the hundreds of GBs when you do that. In the future, Dropbox should make it easier to sync your large data stores.

Ohh, and S3 is way to focuses on utility storage for businesses to be used well for consumers.

I have 160GB of photos, 100GB of music, 120GB of video, and 2TB of recorded TV.