I used duplicity in the past, but the main problem with its incremental backups is that in order to be able to prune the backup history, you need to do full backups regularly to start a new backup chain. That means transferring a full copy of the data.

I switched to restic now, which allows to take incremental backups, but can also remove any snapshot to prune the history. Although it does not support compression, due to its deduplication and removing the need to store multiple full backups, the restic repository takes less space now than duplicity before.