I’ve really been experimenting with my diet in the past few years to improve my running which I just started about 5 years ago. At one point when I was really focused on my microbiome (to the best of my ability with limited knowledge), i experienced changes that made me realize I’d kind of always unknowingly had some symptoms of Chron’s, and I only realized it when they went away. I have long since adapted my diet losing focus on promotion of a healthy microbiome and these symptoms have returned. Coincidentally at the time I was also taking creatine (not as part of my focus on the microbiome) and I subsequently read some antecdotes (no formal studies) of people with Chron’s who got benefits from creatine. But I feel I had similar benefits as they described, only I haven’t previously got them with creatine when on different diets.
Another anecdote I wanted to share, there’s a famous retired UFC fighter, GSP, who got UC and has been very outspoken about it and his recovery (you can find multiple interviews on youtube). He has really found success with intermittent fasting and time restricted eating. I’m not sure if they have formally studied it in humans but there have been formal studies on mice and the benefit of fasting and their microbiome. One really cool study they did was they fasted mice to promote more brown fat, they then transplanted the fasted mice microbiomes into non fasted mice and they too began recruiting more brown fat, that’s mice but it’s amazing to think you can possibly transfer some of the benefits of fasting to nonfasted people through a microbiome transfer.