About.Me Has 400,000 Beta Testers, Opens Doors To All
techcrunch.com
techcrunch.com
Of course this would require the site to create subdomains for users and not directories.
There are also other considerations, mostly related to the user expectations and experience.
In my case, I was able to get a shorter URL ronnieroller.com vs ronnie.me. Makes it easier to say over the phone, twitter, etc.
Make sure you set up the redirects properly. Having multiple URLs that point at the same content could penalize you on search engines for duplicate content (I believe).
I like my about.me. Just wish they offered a couple of more services (mostly tungle.me).