Fuel is fuel, wherever it goes there is a safety consideration.
The last crash I saw on the news had something nasty going on with the engines hitting the tarmac, the above wing placement of the engines is a safety feature as I see it, even though that design choice is more out of consideration for noise - it should be quieter for those living under a flight path.
From the evolution of the bicycle to the mountain bike I can remember that a big, thin-walled tube is stronger and lighter than a narrow, thick-walled tube. I know planes are different, but bigger does not automatically mean heavier.
You could have all of the fuel at the back, behind the passengers and engines. The flight control surfaces and some thrust vectoring could accommodate that.
A U.S company called Boeing know a thing or two about making automatic systems for mitigating against a less than perfect centre of gravity. They went for less than ideally located engines rather than less than ideally located fuel. Allegedly there have been a couple of hiccups with this system but the general idea is that not even the pilots know that there is a computer accounting for changes in centre of lift/gravity, it just works.
On Airbus planes it has always been fly by wire. By 2050 - when this V thing is supposed to go into service - the idea that a human should fly a plane will seem daft, if the computer is doing it all anyway then the plane does not have to be dynamically stable or even balanced from side to side. It should be able to precisely balance out the shear forces no matter what the conditions. You could even turn the thing without banking.
Tongue in cheek criticisms aside, it is better than my student project and a nice thing for KLM's 100 year celebrations.