I'm not sure what you mean by that, but I do know that people with cystic fibrosis have a bad habit of dying of infections from microorganisms that are usually not deemed infectious for most humans. When you google the names of the microorganisms in question, some of them are used by scientists for bioremediation of petrochemical spills.
In other words, they eat petrochemicals. They also think people with CF are tasty as hell while not much caring for "normal" humans, which looks rather suspect to me.
So I suspect that the defect in the CFTR allows plastics and petrochemicals generally, plus metals, to accumulate at higher than normal rates in the CF population. I have run this hypothesis past a guy with a PhD in Biology who suggested that it was not simply straight up crazy talk. He said the function of the CFTR should have some implication for how the body processes metals, IIRC.
(He's a member of HN and is more than welcome to chime in for accuracy's sake if he happens to see this remark, realizes DoreenMichele used to post as Mz and I am talking about him -- hello, nice person with PhD in Biology, and thank you for the awesome feedback.)
Our oceans are getting increasingly polluted with plastic and we increasingly see, for example, dead whales on beaches who are full of plastic and these two things are deemed not unrelated, from what I gather. So it seems that there comes a point past which "normal" humans with a normal CFTR who do not have CF may be unable to avoid similar bioaccumulation of plastics/petrochemicals and other toxic chemicals as I am hypothesizing drive some deadly infections in the CF population.
So, perhaps we can extrapolate from the experiences of the CF community that as our world gets increasingly toxic, it will negatively impact human health generally, including, but not limited to, making us more prone to infection from microogranisms that were never a problem before.
Arguably, this is probably already happening and may be contributing to the rise of Super Bugs. It may not be merely overuse of antibiotics causing this problem. It may also be widespread environmental changes, including but not limited to the increasing prevalence of microplastics across the entire world.