These stress effects on frontal function also make us perseverative—in a rut, set in our ways, running on automatic, being habitual. We all know this—what do we typically do during a stressful time when something isn’t working? The same thing again, many more times, faster and more intensely—it becomes unimaginable that the usual isn’t working. This is precisely where the frontal cortex makes you do the harder but more correct thing—recognize that it’s time for a change. Except for a stressed frontal cortex, or one that’s been exposed to a lot of glucocorticoids. In rats, monkeys, and humans, stress weakens frontal connections with the hippocampus—essential for incorporating the new information that should prompt shifting to a new strategy—while strengthening frontal connections with more habitual brain circuits.
R. Sapolsky, Behave: The Biology of Humans at Our Best and Worst 130 (2017).