Others are looking for options that might minimize overall script / JS size (which is a hallmark of Jason Miller, author of both Preact and HTM).

Another might be to make this easier for beginners. For example, the React docs link to an example HTML page that uses the `babel-standalone` build [0] as a way to try out JSX syntax. However, that's a hefty piece of JS, and it's not at all advisable for real use. HTM might be a good alternative to that.

[0] https://reactjs.org/docs/add-react-to-a-website.html#quickly...

If you're targeting modern evergreen browsers you already have a lot of modern features at your disposal, including ES6 modules, async/await, string interpolation, but we're not using them.

In fact, I'd say that it's way more than "one thing" that you can stop worrying about: you won't need Webpack/Rollup/etc, Babel, NPM/Yarn, Node.js itself, etc.

I'll add another one - the code that comes out is the code that goes in. Remember the days of Coffeescript and minimization before sourcemaps?

When most of your work comes from maintaining a codebase being able to effectively debug your code is crucial and hitting an error in production that is only painfully traced back to development will quickly offset any advantage that framework gives you.