I just built my first AMD machine since the Athlon days with an ASRock Rack EPYCD8-2T [0] motherboard and an AMD EPYC 7281 CPU [1].

I upgraded a VMWare ESXi server hosting FreeNAS from a consumer motherboard with an Intel Core i7 3930K and it was completely painless.

[0]: https://www.asrockrack.com/general/productdetail.asp?Model=E...

[1]: https://www.amd.com/en/products/cpu/amd-epyc-7281