This talks about two major performance concerns in CPUs: control flow and memory access. The transition between the two was my favorite part of the article. It's both funny and accurate.
"If the previous section gave the impression that, say, control flow is a particularly tough problem, but inventive methods can give powerful and practical tools to tackle it… good, that was the intent. In this section I want you to take that expectation and dash it against the rocks — memory is hard."