I think whilst the video is great, the guy missed the deep question raised by the audience.

Using the language in the talk, the question is may be God speak Calculus but is it the only language it/he/she speak?

You have that concern whilst just like a predecessor in post Pythagoras, post Newton, post Einstein, post QM, post AI, we got a strong and strong "understanding" and manipulation of the universe. And those understanding provide us with a great physical well being and more wealth. But is the world a better place?

The tradition question is still why we can send people to the moon but never able to solve the problem of ghetto.

Minor issue: Even he has to admit the assumption of continuity (which mathematically different from differential but mostly do), there are many are discrete and non-differential. Hence God if it/he/she has to cover everything, he must have to speak another language. QED

BTW I like the T-shirt and go to study more calculus. Great talk.