Prolog may suffer from a lack of popularity, but I'd argue that's not because it's lacking in power as a means of expressing an idea. Nor is it due to a hardware paradigm mismatch.

Lisp and its variants (especially Clojure) enjoy increasing popularity for all sorts of general-purpose use. Lisp is merely a particular notation for expressing lambda calculus, and is rather far removed from the realities of Von Neumann hardware.

I'd argue Prolog's demise is due to three facts: (a) the sorts of ideas best expressed in Prolog have diminished due to new languages becoming available, (b) the remaining ideas best expressed in Prolog are only applicable to a narrow set of problems, and (c) Prolog itself isn't the most ergonomic language to use, so it isn't often people's first choice when alternatives are available.