Each one cost me money, but the two in two days cost me thousands. I was hosting a VPS on Rackspace and did everything I could to mitigate it but ultimately the attack stopped because they wanted those resources directed elsewhere.
After the first one, I hooked up with a smart guy on Twitter (http://twitter.com/sempersecurus) that tracks botnets. He allowed me to sinkhole the domain so that he could collect and aggregate the data.
To stay defensive, I put some .htaccess blocks in for countries that are clearly well outside normal buyer patterns. In each case, I know a user (read: a human) saw the campaign and then put the DDoS in place so I hoped, by the .htaccess blocks, to prevent them from seeing the site altogether. But I know I really need to be a much more knowledgable coder to be proficient at deflecting these in the future.