FWIW, I tried microdosing LSD for a while(I'm a programmer and was working from home). I found it to be negative to neutral. I'm probably suffering from ADHD and was looking for increased focus. I didn't find it. I was also a heavy pot user at the time though.

I found it was way too easy to take too much, or to start to feel the effects enough and then want to take more. Even when I kept the dose low, I don't think it led to any increase in productivity. I felt better, sure, but I was looking to get a more permanent sense of accomplishment rather than a short term mood boost.