Like many books in sociology it comes at the problem from multiple perspectives (in different chapters) such that you can't really hold the author to any one clear conclusion.
Big picture, the space shuttle was "unsafe at any speed" from the very beginning. It was estimated that it had a 3% or so chance of blowing up on any flight which turned out to be just about right in hindsight.
One point of the book was that the Space Shuttle had many things wrong with it: they had a committee who's job it was to review all the safety risks and decide which ones they could accept. "Normalization of deviance" was not a bottom-up matter of bad practices, but a formal part of the organization.
If things had gone a little different with the O-Rings then perhaps the "Challenger Disaster" wouldn't have happened, but then it would have been something else. I remember in the early days the thermal tiles were falling off, but after they had done a few flights they convinced themselves it was OK. It was the Columbia disaster that proved that they weren't OK and couldn't ever be OK.