One thing I couldn't find is if it supports wildcard DNS (granted I only did a quick in page search both here and the service description page). Anyone have any insight?
Amazon Route 53 supports wildcard entries for all record types. A wildcard entry is a record in a DNS zone that will match requests for any domain name based on the configuration you set. For example, a wildcard DNS record such as *.example.com will match queries for www.example.com and subdomain.example.com.