Yet at the same time, oxidative stress is linked to numerous diseases.
Biology is hard.
[1] Derek Lowe’s blog (don’t have exact link)
With everything complex, not just living creatures, the real problems are caused by failure to maintain a negative feedback loop properly, and pushing on it doesn't help because the negative feedback is still there almost the same way as normal and has to be to avert complete disaster.
Inflammation is what the body uses to clean out disease and heal itself.
The individual mechanisms used to do this could be considered analogous (but very different from) a short antibiotics regimen.
In the short term or localised to one area it is beneficial. But at a systemic always on level there are negative side effects where these systems begin to overwhelm/damage healthy functions/cells.