1. Load-balance your courses. omscentral.com is an excellent resource for this, and I made sure that the workload never exceeded 20 hours per week (there's crowd-sourced statistics there). Pairing some of the more work-intensive courses with "easier" courses was very helpful, in retrospect.
2. Spread out your courses. It's self-paced! You can take 1 course per semester, skip a semester, etc. Before my kid arrived, I front-loaded and took a 3-course semester.
3. Watch lectures at 2x speed. This was clutch. Most of the content has very slow speakers, likely for clarity, so if you're a native English speaker, watching at 2x speed is usually reasonable.
4. Be okay with mediocre grades. This was probably the most liberating aspect for me. In undergrad, I really cared about my grades. Not caring about grades in OMSCS (or caring more about learning what I want to learn) was more liberating. There were many times I submitted sub-par assignments because they just didn't interest me, or I would rather have spent time with my family.
Hope this helps. If you attend the program, join the unofficial Slack group (I run it). Happy to chat with you offline.