I do everything I can to make typography invisible to me. I do this by converting it all to the same style. I don't allow websites to chose their own fonts. I use Firefox's Reader View whenever possible. I remove all formatting from ebooks and apply my own CSS in Calibre. I'm convinced that the most legible typography is the one you're most familiar with, and if you consistently read the same typography it will become the metaphorical crystal. The actual design of the type matters very little.