It's not so much a "problem" as it is "physics". If the stabilizers are forcing the nose down, and the pilot pulls back on the stick (engaging the elevators) to pull the nose up, the forces exerted on the stabilizer are such that, in extreme cases, human force is insufficient to move the manual wheel.
This is extremely (EDIT: No longer) well documented by Boeing going back decades, and it presents solutions of either: 1) reengaging the electronic stabilizer trim and trimming electronically back to a point where the forces are manageable, then cutting electronic trim again, or 2) relaxing the stick, letting the nose go the way the stabilizers want it to, which slackens the force, and makes cranking the wheel manually doable. Great if you're stabilizers are trimmed severely nose down at a height of 40,000 feet; less great at a height of 1,000 feet. (EDITED TO ADD: Apparently this information & procedure was removed from Boeing's manuals after the 1980s, and pilots no longer train on it, as the issues that led to its necessity were thought solved. The MCAS apparently has reintroduced the need for them.).
This is compounded by a new change in the 737-MAX: in prior 737 series aircraft, there are two stab trim cutout switches: one to cut the autopilot's ability to command the stabilizer trim, the other to cut electronic power to the stabilizer trim adjustment entirely, so you could stop the autopilot from changing the trim but still retain electronic control and not need to worry about the manual crank forces. The two switches are MAIN ELEC and AUTO PILOT.
In the MAX, this changed, and it's now an all or nothing setup: you have to kill electronic power to kill autopilot commands to the stabilizer. The two switches are now PRI and B/U. Both must be cut out to stop any stabilizer runaway, including MCAS runaway.
This all seems to add up to Boeing's narrative of "The MCAS is safe, pilots just need to know to hit the stab trim cutout" being grossly insufficient. They must cut it at a moment where the stabilizer isn't grossly mistrimmed with respect to level flight, OR they may well need to re-engage it and race the MCAS to get into a close-to-proper trim setup prior to cutting out the stabtrim and assuming manual trim control.