People don't seem to grasp exactly how variable this can be, or that it's a very inaccurate guessing game to predict a priori how much disruption this can cause.
The best sources of data are your historical responses and those of your family members, and even then, it's really unreliable.
Historically, I have had extremely few side effects from any medication, cold turkey (unintentionally, except for v. small doses of v. safe meds) or tapered off, and I have unfortunately had occasion to try a large spread of psychopharmacology.
Some of those medications either did nothing for me from their primary/intended effect set, while they were extremely effective for family members - not just limited to psychiatric medications, but they do have a great deal of variability in response compared to some.
Some medications that work on me but have no obvious secondary effects than sometimes mild sedation (opioids) do nothing for some of my immediate family (positive or negative) or are extremely powerful on others.
Some medications that leave me with no positive or negative emotional responses to anything are extremely effective for some immediate family members and even worse for others.
Some medications that are strongly sedating for some of my family members (antihistamines) have never done anything useful for me.
Some medications (both in the ??RI classes and a couple of atypical ones) that are helpful or neutral for me induce manic or depressive episodes in family members.
This is a hard problem, and it's going to take a good amount of work and better data curation (e.g. not asking a patient what they took for how long and how well it worked by word of mouth as a primary source) before we get any better at guessing.