If you're not already using it, check out `django-extensions`. You can use `./manage.py shell_plus --notebook` to launch a Django-friendly Jupyter notebook.
From there you can prototype with extreme ease and confidence.
I have also built a trivial custom model Manager so I can do stuff like:
User.objects.all().to_dataframe("first_name", "last_name", "email")
Honestly I can't see myself being even slightly tempted to move to something else unless I can replicate this workflow.