One major issue that the US has run into with deploying that strategy, in the absence of great power opponents, is that the largest long-term costs are not the airframes, but pilots and pilot training. An F-16 pilot isn't cheaper than an F-15 pilot, and getting hours for an F-16 pilot isn't cheaper than getting hours for an F-15 pilot, other than the lower fuel cost for the F-16.
That said, the F-15X that the USAF is procuring is basically going to be used as a lower-cost-than-F-35 "missile truck," so not incompatible with what you suggest.