The book Antifragile is all about this. His advice for entrepreneurs specifically is to "avoid your risk of ruin". Starting a business is never guaranteed to succeed, and if you stake your entire life savings on one business venture and take out loans, you could just get unlucky regardless of EV. If you, say, kept a part time job and worked on your business in the rest of your time and had infinite runway, you'll eventually succeed if you don't quit.
This idea has strongly impacted the way I face decision making.
Secondly we'll define perfect poker as game theory optimal poker. Game theory optimal poker better known as GTO poker is by definition unexploitable. In the long run, two people playing GTO poker against eachother neither player will win money.
GTO poker is not necessarily the form of poker that will make the most money. Given that 99% of the time you are playing versus amateurs who do not know sound poker strategy you can adjust your play style in order to exploit the mistakes of the other players. When you adjust you are actually exposing yourself to better players. Better players can identify how you are adjusting to take advantage of bad players and in turn adjust themselves to take advantage of the weaknesses you are introducing into your game.
About a 95% favorite.