If we have fusion power, durable permanent space habitats, and the technology to harvest materials from asteroids, then traveling to the next star system doesn't seem so far-fetched anymore. If we could just reach 0.1c, we could make it to Alpha Centauri in less than 50 years. Once we make it there, if we're already comfortable living in space, we don't even need to worry about terraforming or anything lengthy and complicated like that, we can just harvest asteroids and build more space stations and ships.
Not a physicist, but I see Project Orion could have reached 0.33% of the speed of light. Would it be realistic to extend that design to accelerate to 0.1c?