After working on a quite large application and having to use lots of assert(isinstance(arg, type) at the beginning of almost every function, I began to think that a strong type system is very much needed for large projects. I believe this was one of the reasons why Twitter moved from Ruby to Scala.
I still love to use Python for hacking something quick for myself. But I also look at some popular strongly-typed languages now and hope to get better at one of them soon.