Here are two relevant blog posts we wrote while establishing our direction and attitude about 6 months ago:
* http://blog.quplo.com/2010/04/our-philosophy-design-in-the-b... - what designing in the browser is, why we think it's important, and some other references to thought leaders talking about it.
* http://blog.quplo.com/2010/04/why-were-not-building-yet-anot... - why we think the world doesn't need yet another WYSIWYG, drag-and-drop "prototyping" tool.
Anyway, if you subscribe to the Mockup-in-Markup idea, check out our app, Quplo. It's an online app where you write HTML and CSS and a little custom markup language specifically made for prototypes (eg. <page>, <layout>, <var> etc). You can import an existing website and redesign it quite easily; everything you make is accessible from yourprototype.quplo.com (with or without a password). If you like it, head to http://dev.quplo.com/freeupgrade for a free beta-period upgrade to a higher plan!