Changing yourself due to increased neuroplasticity is a feature, not a bug. That isn't the same thing as "overdosing."
The only guarantee is that your ability to change increases due to increased neuroplasticity. Whether the change is good or bad is ultimately up to you, which is why I think if these drugs were to be legalized that the intake should happen in conjunction with in-person therapy in a controlled environment and not at all something you'd just pickup at a pharmacy and take on your own like anti-depressants are today.