This is a bit like comparing street amphetamine powder with prescription adderall. People are willing to pay for a pure product measured precisely in laboratory, not cut with other dangerous chemicals delivered as a pill.
However, ketamine is widely used as an anesthetic, so I think the "cheap to make" refers to Ketamine redirected from the pharma market to illicit channels, in which case "making" ketamine is just drying the solution to crystalize the sole ingredient.