I have Carplay in my car - which I like a lot - however I'm under no illusion that using it while driving, is much much worse in terms of the amount of time it takes my attention from the road, than a similar physical control.
There are also voice commands so yes.
In the case of climate control you can use muscle memory if you really want to, to hit a button always ready in the same place on the edge of the screen, and then use the hardware buttons from there, so yes. Personally I would glance at the bottom edge of the screen (center) while approaching the button with my finger, but you don’t have to do this, and you can easily do it with a flick of they eye while traffic is in a calm pattern, at a moment of your choosing. It’s not like your eyes need to wildly search the screen for the button... it’s right there in a known fixed place.
People have such far out misconceptions about Tesla cars. It’s bizarre.
Btw I have to take my eyes off the road when I check the speed and the mirrors and that is something I do quite often and considering the behavior on the roads more drivers should.