Use C# with Godot. I am personally looking forward to F# with Godot. GDScript is close enough to Python for me, I had no problem with if from the start, and it integrates really well with Godot.
Whereas I can do some desktop animation stuff with Godot without caring much (that's one of the reasons I'm interested in MIDI support), if I were to go beyond the hobby phase I'd definitely target iOS first...