I developed eye floaters about a year ago that are annoyingly noticeable against any page with a white background. The Dark Reader extension (https://darkreader.org/) has been a life saver for me, and I've found my eyes to be less tired overall when using it, too.

My only wish now is for a way to invert PDF colors on Mac - I haven't found a good way to do that short of inverting all screen colors, which messes up all the other apps that do have a dark/night mode.