Long answer: Good question. I typeset the print version of the one book I've self-published in LaTeX, because I love books and didn't want to contribute to the abysmal typesetting of KDP and bulk self-publishers.
Converting to LaTeX is not that hard, the problem is that unless you write everything in Markdown or Orgmode in the first place, you'll you have to maintain two sources - one for the ebook and a LaTeX version. I'm using some special word processing software, though, so I cannot write in Markdown.
My biggest conundrum is that of many hobby authors, I presume. I don't like Amazon and don't want to aid them in destroying the print book market. At the same time, for German self-publishers there are not many realistic alternatives to Amazon. So thanks a lot for the links. I am definitely looking for ways to distribute my works (for free) in alternative ways.
Short answer: Yes, in the future I'll probably not typeset my books by hand if I self-publish them. It's too much work. But the decline in typesetting quality caused by self-publishers bothers me a lot. And don't even get me started on book binding, cover design, etc.