> Right but what happens when you no longer inputting calories and thus no longer have high insulin? Then you start burning the fat again. You can only keep your insulin levels pathologically elevated if you are eating enough to support that over the long term, regardless of when you eat.

No, diabetics have an elevated insulin levels for hours after a meal. Like, after 4 hours it's still at the level a non-diabetic peaks at after 0.5-1 hour. Eating many meals will keep your insulin levels high all-day.

> Again, your body is very good at supplementing energy needs with fat when it needs to. Again there is no study showing meal time having any impact when calories are balanced, and several confirming the opposite.

Your body is very bad at burning fat in the presence of insulin. Meal time is only important as to not keep your insulin level elevated all the time.

> Your body adapts to a short term situation (a meal and the small post-prandial period) but in the long term (24 hour period) it makes zero difference.

If you are eating all the time, the short term situation becomes the long term situation, not barely on 24 hour periods but for years on end. This is especially true for diabetics and pre-diabetics, as their insulin level will lower way slower.

This is not to say you can't avoid the whole situation by lowering your calories BEFORE you become diabetic. It may actually be the best way, but the science is far from being set because it's such a complex problem.

> Yes but it's also reversible by, shockingly, increasing caloric demand.

It's reversible by either supplementing more food or allowing your body to access its own resources (low insulin!). Increasing caloric demand (exercise!) will help insofar as you're burning of sugar -> less insulin.

> To be very clear, the proof required for what you are suggesting is a study with a minimum of 2 groups eating the same exact meals but at different times, and being forced to finish the entire meal and experiencing different outcomes.

While I'm not a fan of isocaloric studys, this should work, yes. You would also have to factor in a lot of other parameters, like established insulin resistance (probably using Kraft-Patterns)

> This has never happened, and based on our current understanding of metabolism never will. Maybe it would change, but this would be a massive massive change in our understanding of how the human body deals with energy.

I'm genuinely interested as to what your understanding of insulins / glucagons effect on your body's ability to access fat is.