It is possible. As others said, you will have a somewhat of a tough time getting an interview, but if you get one and nail it, you will get an offer just the same. As to how to get an interview in such situation? - be very proactive and find alternative ways to get your resume in front of the eyes of engineers or engineering managers. If you rely only on submitting through the standard Jobs page, your resume will most likely never make it through the layers of automated software and recruiters filtering. Find a friend that works in one of these companies and ask them to help you out, lurk in the groups where employes frequent and try to make a name for yourself, make sure one of your apps is moderately successful and meets a need for one of these companies.

Note that getting an offer is also contingent on your eligibility to work in US. If you are not a US citizen or a green card holder, the requirements to get an H1 visa are to have the equivalent of four years of education, where each three years of work experience counted as a year of education. (There are other H1 class visas, but they are not as common in the computer industry) But the company has to like you really a lot to go through the trouble in that case...

And since you managed to pique my interest, Id be curious to look at your resume. I'll leave out the part of figuring out how to send it (without it being caught by the junk filters) as an exercise to you. Shouldn't be that hard..