I assume it's the same method they've successfully used to eliminate Multiple Sclerosis.
https://www.bbc.com/news/health-43435868
How are we not pumping billions more into stem cell research?!?
https://www.bbc.com/news/health-43435868
How are we not pumping billions more into stem cell research?!?
The procedure for MS is HSCT. It's erroneously called "transplant," as it actually is stem-cell rescue. The basic idea is to extract your own stem cells, kill of most (not all) of your existing immune system, and then re-infuse your stem cells to "reinstall" your immune system. Hopefully before you get an infection while you don't have any defenses.
This treatment has been shown to be effective for the most mild form of MS, Relapsing Remitting (RRMS), and only in the early stages of the disease. It's relatively risky, and if we were to do the procedure for everyone diagnosed with RRMS today, hundreds (if not thousands) of people would die from the treatment. Either from complications from the procedure, or from increased instances of cancer years down the road, since the poison part of the treatment is known to be carcinogenic.
Meanwhile, there is Rituximab, which is a monoclonal antibody targeting the CD20 protein that has had its patent recently expire. This means it can be manufactured as a generic. Clinical trials recently run in England have shown that not only is it extremely effective at controlling the disease in the most mild form (RRMS), but CD20-targeting monoclonal antibodies are the only drugs known to be in any (meaningful) way effective for the more serious forms of the disease, Secondary Progressive (SPMS) and Primary Progressive (PPMS).
Given the choice between HSCT or Rituximab, in terms of effectiveness, safety and cost, Rituximab wins as a treatment for MS, hands-down.
For those stuck in the United States, the FDA will let you get Ocrelizumab (Ocrevus), which is basically Rituximab tweaked enough so that Genentech could get patent protection for it. With that patent protection, they got the financial incentive to run it through the FDA approval process so they can now sell it to you for the bargain price of about $80,000 per year. It's just about as effective as Rituximab and maybe only a little more dangerous.
I've been looking into MS drugs recently for someone I know, and Rituximab definitely sounds like the better option.
/sarcasm
> In the United Kingdom this amount cost the NHS approximately £182 in 2015.[9] The average wholesale price in the United States of a typical treatment for rheumatoid arthritis (1,000 mg IV dose, 2 weeks apart) would have been $14,100 a month in 2014 ($705 per 100 mg)[10] but the patent expired in 2016.[
So Rituximab was never approved by the FDA? I assume it too had once been under patent, and its manufacturer would have tried to get it approved.
W. vetoed multiple embryonic stem cell research bills during his administration, the Catholic Church still formally opposes it[0], as well as the Southern Baptist Convention.
[0]: http://www.usccb.org/issues-and-action/human-life-and-dignit...
https://www.scientificamerican.com/article/human-stem-cells-... (Human Stem Cell Breakthrough: No Embryos Required, 2007)
[1] I'll also add: the question of whether destroying embryos for research is moral is not a religious one, but rather a political issue on which religions have strong opinions. So long as the government makes it illegal to kill people, it must as a purely political question define what a "person" is and what the exceptions are to that rule. Thus, the death penalty is a political issue rather than a religious issue, even though e.g. the Catholic church and several protestant denominations officially condemn it.
The rationalization against embryonic stem-cell research, or against first-term abortion as commonly expressed, is in almost every case drawn from religious motivation. I don't know why you're claiming they're primarily political. They're political in that people of faith will export religious dogma into the political sphere, but that doesn't make it primarily a political issue like you suggest.
It's possible to make a (tenuous) secular argument against abortion (though it's pretty rough going and is easy to demolish), but... can you put forward any plausible secular argument against embryonic stem cell research, except by assuming the conclusion you want — which is that embryonic stem cells are largely problematic, and adult stem cells can be made to work pretty well, for most things?
As to the secular argument against embryonic stem cell research: embryos are both human, and alive. Both facts are undisputedly true as a matter of biology. So the general rule against killing humans should apply unless some other exception is implicated. What those exceptions are is a political issue, even if it happens to also be a religious issue.
Note also that the secular justification for abortion doesn’t carry over to stem cell research. With abortion, there is the argument that, whatever the nature of the embryo happens to be, it doesn’t outweigh the mother’s right to bodily autonomy. But these embryos are already removed and frozen. Destroying them for research requires a different justification than destroying them for purposes of abortion
The pain and suffering argument (not that you've raised it) is nonsense as well, since pain and suffering during the murder of other animals in socially acceptable contexts is not regarded as very serious, except (sort of) by the Jains. And those animals, even insects, have more cognitive/sensory capacity than a human embryo (which has zero).
The only foothold the religious argument can rely on, without falling to oblivion, is the notion of future potential of a human embryo. But that raises other issues. The embryo won't get there on its own. It requires 9 months of symbiosis with another human with her own interests, or perhaps in the future there will be some option of 9 months of extremely expensive artificial incubation.
When you descend into the insanity of judging based on (uncertain) future potential, it's unclear why, as a matter of religious doctrine, destroying/wasting embryos/zygotes is forbidden, but wasting gametes is perfectly acceptable. If a woman's interests, ability to support a child, and relationship with (potentially) a spouse (who will co-raise and co-support the child) are not relevant in the determination of whether a future child is worth seeing through, why then would you stop at banning abortion? Why stop at banning contraception, even? Women, if maximizing potential future children is paramount, should never ever be allowed to say no, to anyone, ever, should they?
Of course, the reason for that difference in treatment is the (convenient) concept that the soul enters upon formation of a zygote, but that is a purely religious concept, and now we're back in religious la-la land, not in secular-argument land like you claimed. So about those tumors with souls...
Regarding the motive for the embryonic stem cell ban — it's not clear that the actual religious objection is primarily concerned with preventing destruction. Research involves splitting and growing the cell lines, which results in branches of the cell line being experimented on and then killed. If each of these isolated cell clusters has a soul, isn't ongoing experimentation just as bad, and actually worse, than simply killing the single master cell line? The latter would result in one death. Ongoing experimentation results in potentially unlimited deaths.
It seems like the real intent behind the federal funding ban for research involving new embryonic stem cell lines is to prevent their creation in the first place, knowing that once created all the options are bad (according to religious dogma) and result in the destruction of one or many soul-vessels. But to be ideological consistent, wouldn't you want to prevent the creation of never-to-be-gestated soul-vessels by splitting, too, in addition to preventing their initial creation? If so, W's ban makes no sense.
If you agree that identical twins have separate souls and tumors don't have souls, I don't know what you (or anyone against embryonic stem cell research or IVF which has similar issues) are doing, other than grasping at biological partial-realities trying to defend your religious dogma.
it seems to use your own stem cells, and is not used because of its risk factor