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Why the focus on niche languages / frameworks? Why not make your life easy and use Qt (C++) or Electron (JS)?

I don't really know C++ and I'm sick of JS. But I will take a look into Qt.

You can also use Qt from Python using PyQt or PySide, which is officially supported as of recently - https://www.qt.io/qt-for-python

There are also Qt bindings for a bunch of other languages, but Python seems to be the best supported after C++